Ocular microsphere delivery system
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United States of America Patent
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Nov 17, 1998
Issued Date -
N/A
app pub date -
Sep 19, 1995
filing date -
Dec 8, 1993
priority date (Note) -
Expired
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Abstract
A sustained release drug delivery composition and a method of making same are provided which comprises microspheres containing a pharmaceutically active agent, a core of a ion-exchange resin and a polymeric coating completely surrounding the core wherein the coating is water-insoluble and hydrolytically stable in physiological environments. The coating is non-erodible in physiological environments and is characterized by a diffusion constant suitable for the pharmaceutical agent to diffuse from the core to an aqueous environment at a predetermined release rate.
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