Immunoconjugates which neutralize HIV-1 infection
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United States of America Patent
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Nov 10, 1998
Issued Date -
N/A
app pub date -
Mar 4, 1993
filing date -
May 29, 1987
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Abstract
Monoclonal antibodies are revealed which bind to the gp 120 protein on the envelope of HIV-1. These antibodies neutralize HIV-1. They inhibit the infection of T cells, and also inhibit syncytium formation. Further, the antibodies are group-specific and neutralize different strains and isolates of HIV-1. These antibodies have a variety of uses, including the treatment and prevention of AIDS and ARC. The antibodies are used in immunotoxins which are specifically toxic to HIV-1 infected T cells.
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