Importance

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Abstract

A quinuclidine derivative represented by the following general formula (I), a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof, which has strong squalene synthase inhibiting activity and is useful as a cholesterol lowering agent without causing side effects. ##STR1## (Symbols in the formula represent the following meanings; R.sub.1 : a hydrogen atom, a halogen atom or a lower alkyl group, R.sub.2 : a hydrogen atom, a hydroxyl group or a lower alkoxy group, . . : a single bond or a double bond, with the proviso that R.sub.2 does not exist when . . . is a double bond, X and Y: the same or different from each other and each represents a bond, an oxygen atom (--O--), a carbonyl group (--CO--), a group represented by the formula --S(O).sub.p -- or a group represented by the formula --NR.sub.3 --, p: 0, 1 or 2, R.sub.3 : a hydrogen atom or a lower alkyl group which may have a substituent, A: a saturated or unsaturated lower alkylene group, a group of the formula --(CH.sub.2).sub.m Z(CH.sub.2).sub.n -- or a group of the formula --(CH.sub.2).sub.m Z(CH.sub.2).sub.n CR.sub.4 =, Z: an oxygen atom (--O--), a group of the formula --S(O).sub.q --, a carbonyl group (--CO--) or a group of the formula --NR.sub.5 --, R.sub.4 : a hydrogen atom, a halogen atom or a lower alkyl group, R.sub.5 : a hydrogen atom or a lower alkyl group, m and n: the same or different from each other and each is 0 or an integer of 1 to 5, m+n: an integer of 1 to 5 q: 0, 1 or 2, with the proviso that, when either one of X and Y is a bond, A is a group represented by the formula --(CH.sub.2).sub.m Z(CH.sub.2).sub.n CR.sub.4 =.)

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First Claim