Gene therapy of tumors with an endothelial cell-specific, cell cycle-dependent active compound
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United States of America Patent
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Nov 3, 1998
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N/A
app pub date -
Apr 18, 1997
filing date -
Aug 26, 1994
priority date (Note) -
Expired
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Abstract
A DNA sequence for the gene therapy of tumors is described. In its essential elements, the DNA sequence is composed of an activator sequence, a promoter module and a gene for the active substance. The activator sequence is activated, in a cell-specific manner, in proliferating endothelial cells or in cells which are adjacent to these endothelial cells. This activation is regulated by the promoter module in a cell cycle-specific manner. The active substance is an inhibitor of angiogenesis or a cytostatic or cytotoxic molecule. The DNA sequence is inserted into a viral or non-viral vector which is supplemented with a ligand which possesses affinity for the activated endothelial cell.
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