24-and 25-substituted avermectin and milbemycin derivatives

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United States of America Patent

PATENT NO 5830875
SERIAL NO

07429919

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Abstract

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Novel avermectin and milbemycin derivatives are disclosed, where the C-24 and C-25 carbon atoms are substituted by hydrogen, alkyl, alkenyl, substituted alkyl or substituted alkenyl groups. These compounds can be further substituted at the 4'-, 5-, 13-, and 23-positions. The new C-24 and C-25 substituted avermect prepared by cleavage of known and suitably protected avermectin and milbemycin compounds. The new compounds are potent anti-parasitic agents, in particular, the compounds are anthelmintic, insecticidal and acaricidal agents.

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Patent Owner(s)

Patent OwnerAddress
MERCK SHARP & DOHME CORP126 EAST LINCOLN AVENUE RAHWAY NJ 07065-0900

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Mrozik, Helmut Matawan, NJ 27 320
Shih, Thomas L Edison, NJ 7 87

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