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Abstract

The present invention relates to 1) pharmaceutical compositions and methods for chemotherapeutic agents and 2) pharmaceutical compositions for biological agents, particularly those whose target cells or tissues are resistant to the biological agent. The invention is targeted to overcome the resistance to biological agents that are developed by neoplasms and microbial infections. The formulation contains a biological agent and a polyether block copolymer. The block copolymer comprises an A-type linear polymeric segment joined at one end to a B-type linear polymeric segment; wherein the A type polymeric segment is hydrophilic, has repeating units which contribute an average Hansch-Leo fragmental constant of about 0.4 or less, and has a molecular weight contribution between 30 to about 500. The B-type segment is of relatively hydrophobic character, has repeating units which contribute an average Hansch-Leo fragmental constant of about -0.4 or more and a molecular weight contribution of about 30 to about 500, and has repeating units for each polymeric segment that comprise an ether linkage. The compositions may comprise chemotherapeutic agents, cytotoxic drugs, microbial treating agents, and a second biological agent.

First Claim