Compositions for passive immunotherapy

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United States of America Patent

PATENT NO 5817312
SERIAL NO

08949862

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The direct, concentrated local delivery of antibodies, and pooled human immunoglobulins in particular, to tissue surfaces (e.g., wounds, burns, etc.), and biomaterial implant surfaces significantly decreases the rate of infection at those sites and enhances healing. The immunoglobulins serve to opsonize circulating infectants for phagocytosis and killing, prior to microbial adhesion and biofilm formation, and neutralize bacterial toxins. The treatment methodology results in reduced inflammation, reduced complement and tissue damage, and reduced rejection of biomaterials and transplants.

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Patent Owner(s)

Patent OwnerAddress
LONDON HEALTH SCIENCES CENTRE RESEARCH INCLONDON

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Giridhar, Girish Manassas Park, VA 4 43
Gristina, Anthony G Reston, VA 9 197

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