Sphingosomes for enhanced drug delivery
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United States of America Patent
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Sep 29, 1998
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app pub date -
Sep 17, 1997
filing date -
Jun 20, 1994
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Abstract
Liposomal formulations having extended circulation time in vivo and increased drug retention are comprised of sphingomyelin and cholesterol and have an acidic intraliposomal pH. The formulations have enhanced stability and thus are used in methods which provide improved drug delivery and more effective treatment. The delivery of ciprofloxacin, and alkaloid drugs, particularly swainsonine, vincristine and vinblastine, is significantly improved.
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