Time-resolved diffusion tomographic imaging in highly scattering turbid media

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United States of America Patent

PATENT NO 5813988
SERIAL NO

08618471

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Abstract

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A method for imaging objects in highly scattering turbid media. According to one embodiment of the invention, the method involves using a plurality of intersecting source/detectors sets and time-resolving equipment to generate a plurality of time-resolved intensity curves for the diffusive component of light emergent from the medium. For each of the curves, the intensities at a plurality of times are then inputted into the following inverse reconstruction algorithm to form an image of the medium: X.sup.(k+1).spsp.T =?Y.sup.T W+X.sup.(k).spsp.T .LAMBDA.!?W.sup.T W+.LAMBDA.!.sup.-1 wherein W is a matrix relating output at detector position r.sub.d, at time t, to source at position r.sub.s, .LAMBDA. is a regularization matrix, chosen for convenience to be diagonal, but selected in a way related to the ratio of the noise, to fluctuations in the absorption (or diffusion) X.sub.j that we are trying to determine: .LAMBDA..sub.ij =.lambda..sub.j .delta..sub.ij with .lambda..sub.j =/<.DELTA.Xj.DELTA.Xj> Here Y is the data collected at the detectors, and X.sup.k is the kth iterate toward the desired absoption information.

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Patent Owner(s)

Patent OwnerAddress
RESEARCH FOUNDATION OF CITY COLLEGE OF NEW YORK THE79 FIFTH AVENUE NEW YORK NY 10003

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Alfano, Robert R Bronx, NY 141 7099
Cai, Wei Bronx, NY 73 1216
Das, Bidyut B Flushing, NY 3 313
Lax, Melvin Summit, NJ 3 246
Liu, Feng Bronx, NY 583 7601

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