Process for the purification of oligomers
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United States of America Patent
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Sep 22, 1998
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app pub date -
Dec 30, 1994
filing date -
Dec 30, 1993
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Abstract
Methods for purifying an oligomer by normal phase column chromatography on a support selected from polyhydroxyethyl aspartamide, hydrophilic silica and silica from an oligomer impurity having a different nucleoside sequence are described. These methods are based upon the different retention times of the oligomer and the impurity on the column.
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