4-amino-fluorobenzamides and their use as cytotoxic prodrugs
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United States of America Patent
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Sep 22, 1998
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N/A
app pub date -
Dec 21, 1995
filing date -
Apr 30, 1993
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Expired
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Abstract
The invention provides a compound which is a 3-fluorobenzamide of the formula (A) ##STR1## wherein R-NH is the residue of an .alpha.-amino acid R-NH.sub.2 or oligopeptide R-NH.sub.2, and M is a nitrogen mustard group of the formula ##STR2## wherein Y and L, which may be the same or different in a molecule, are leaving groups; or a pharmaceutically acceptable salt thereof. The compounds are useful as prodrugs for treating cancer.
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