Percutaneously absorbable preparation containing cohesive strength improving agent
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United States of America Patent
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Sep 22, 1998
Grant Date -
N/A
app pub date -
Mar 12, 1997
filing date -
Jul 22, 1994
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A percutaneously absorbable preparation which contains norethisterone, estradiol or ester thereof, each of which is highly absorbable percutaneously, can readily be stuck to the skin, and is lowly skin irritating. It is prepared by applying a pressure-sentitive adhesive layer comprising a drug and a pressure-sensitive adhesive to one side of a support. The drug comprises at least one member selected from among norethisterone, estradiol and pharmacologically acceptable esters thereof, while the adhesive comprises a copolymer composed of 20-55 mol. % of vinylpyrrolidone and 80-45 mol. % of alkyl (C.sub.4 -C.sub.18) (meth)acrylate. The adhesive layer further contains a sorbifacient comprising 0.1-10 wt. % of at least one member selected from among dicarboxylic acids, hydroxy carboxylic acids, plyoxyethylene alkyl ethers and amide compounds and 5-40 wt. %, both based on the adhesive layer, of a higher fatty acid ester prepared from a C.sub.10 -C.sub.18 fatty acid and a C.sub.1 -C.sub.20 alcohol and also contains a cohesive force improver.
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