Bacteriophage genotypically modified to delay inactivations by the host defense system
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United States of America Patent
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Sep 22, 1998
Issued Date -
N/A
app pub date -
Apr 12, 1996
filing date -
Apr 5, 1994
priority date (Note) -
Expired
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Abstract
The present invention is directed to bacteriophage therapy, using methods that enable the bacteriophage to delay inactivation by any and all parts of the host defense system (HDS) against foreign objects that would tend to reduce the numbers of bacteriophage and/or the efficiency of those phage at killing the host bacteria in an infection. Disclosed is a method of producing bacteriophage modified for anti-HDS purposes, one method being selection by serial passaging of a bacteriophage, and the other method being genetic engineering of a bacteriophage, so that the modified bacteriophage will remain active in the body for longer periods of time than the wild-type phage.
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