Importance

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Abstract

A peptide of formula: A--D--X--D--Mrp--B (I) A--D--X--D-.beta.Nal--B (II) E--D--X--Mrp--NH.sub.2 (III) wherein A is hydrogen, 2-aminoisobutyryl, or 4-aminobutyryl; D relates to the dextro isomer; X is Mrp, wherein Mrp is a 2-alkyltryptophan of formula (IV): ##STR1## wherein R is hydrogen, CHO, SO.sub.2 CH.sub.3, mesitylene-2-sulfonyl, PO.sub.3 (CH.sub.3).sub.2, PO.sub.3 H.sub.2, wherein R.sub.1 is a C.sub.1 -C.sub.3 alkyl group, or wherein X is a residue of protected serine, Ser (Y), wherein Y is benzyl, p-chlorobenzyl, 4-methoxybenzyl, 2,4,6-trimethoxybenzyl, or tert-butyl; B is NR.sub.2 R.sub.3, wherein R.sub.2 and R.sub.3, may be the same or different, are hydrogen, a C.sub.1 -C.sub.3 alkyl group, an OR.sub.4 group, wherein R.sub.4 is hydrogen, a C.sub.1 -C.sub.3 alkyl group or the C--Lys--NH.sub.2 group, wherein C is Phe, Mrp or D--Mrp; E is hydrogen, GAB or D--Mrp, and addition salts with pharmaceutically acceptable organic or inorganic acids of the peptide.

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First Claim