Antiinflammatory, immunosuppressive and antialleric 16, 17-alkylidioxy-steroids
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United States of America Patent
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Sep 1, 1998
Grant Date -
N/A
app pub date -
Jun 2, 1995
filing date -
Dec 24, 1992
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Abstract
Compounds of formula I ##STR1## where R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, n, and are as defined herein, their use as antiinflammatory, immunosuppressive, and antiallergic agents, pharmaceutical compositions comprising them, and methods for their preparation comprising irradiating compounds of formula II ##STR2## under an inert atmosphere, in the presence or absence of a compound of formula R.sub.3 --S--S(O).sub.m --R.sub.8, where R.sub.7, R.sub.8, and m are as defined herein, and methods for their preparation comprising oxidizing, reducing, halogenating, or alkylating compounds of formula I are disclosed.
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