Inhibitors of NAALADase enzyme activity
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United States of America Patent
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Aug 18, 1998
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Dec 31, 1996
filing date -
Dec 31, 1996
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Abstract
The present invention includes compounds, compositions, and methods of treatment for glutamate abnormalities and associated nervous tissue insult in a animal by inhibition of NAALADase enzyme. Compositions include phosphonate derivatives and mixtures thereof that inhibit NAALADase enzyme activity and their use for treating glutamate abnormalities such as created by global and focal ischemia and for treatment of prostate disease and prostate cancer by inhibition of NAALADase enzyme.
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