Labeled chemotactic peptides to image focal sites of infection or inflammation

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United States of America Patent

PATENT NO 5792444
SERIAL NO

08140000

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Abstract

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The invention relates to a method of detecting a site of infection or inflammation, and a method for treating such infection or inflammation, in an individual by administering to the individual a diagnostically or therapeutically effective amount of detectably labeled, therapeutic, or therapeutically-conjugated, chemotactic peptide that accumulates substantially at the infected or inflamed site, said chemotactic peptide having the general structure X--Y--Leu--Phe--?Z!.sub.n --W wherein: X is an amino protecting group, Y is an amino acid residue, Z is a spacer sequence, n is 0 or 1, and W is a labeling or attachment substituent.

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Patent Owner(s)

Patent OwnerAddress
GENZYME CORPORATION450 WATER STREET CAMBRIDGE MA 02141

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bridger, Gary J Bryn Mawr, PA 50 757
Derian, Claudia K Hatboro, PA 6 46
Fischman, Alan J Boston, MA 42 308
Fuccello, Anthony J Princeton, NJ 1 20
Hernandez, Pedro E Malvern, PA 4 85
Higgins, III John D West Chester, PA 9 207
Kroon, Daniel J Flemington, NJ 4 46
Larsen, Scott K West Chester, PA 8 244
Rubin, Robert H Brookline, MA 10 161
Solomon, Howard F New Hope, PA 3 130
Strauss, H William Skillman, NJ 20 732

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