Method for reducing neuronal degeneration associated with seizure
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United States of America Patent
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Jul 28, 1998
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N/A
app pub date -
Sep 21, 1995
filing date -
Sep 21, 1995
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Expired
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Abstract
The invention provides a method for regulating neuronal degeneration resulting from injury to nervous tissue. The method includes regulating the expression or activity of protease, preferably tissue-type plasminogen activator (tPA), by microglial cells. Alternatively, the method involves regulating microglial activation in response to injurious conditions. The method, in an alternative embodiment, includes detecting tPA expression or activity, or detecting microglial activation. In addition, the method includes assessing the susceptibility of a human or animal subject to seizure, and may involve detecting the activity or expression of tPA, and may further involve comparing a measured level of tPA expression or activity with a reference level associated with a given probability of seizure.
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