Rigid bifunctional chelating agents

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United States of America Patent

PATENT NO 5783169
SERIAL NO

08506889

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Abstract

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Bicyclo?2.2.2! octane-2,3 diamine-N,N,N',N'-tetraacetic acids (BODTA) and bicyclo?2.2.1! heptane-2,3 diamine-N,N,N',N'-tetraacetic acid (BHDTA) are chelating agents useful in forming detectably labeled bioconjugate compounds for diagnostic and therapeutic purposes. New compounds and processes of forming BODTA and BHDTA are disclosed. Radioimmunoconjugates of the present invention show high and prolonged tumor uptake with low normal tissue uptakes.

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Patent Owner(s)

Patent OwnerAddress
BROOKHAVEN SCIENCE ASSOCIATES40 BROOKHAVEN AVENUE BLDG 460 UPTON NY 11973-5000

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Mease, Ronnie C Fairfax, VA 50 529
Srivastava, Suresh C Setauket, NY 64 623
Sweet, Mark P Coram, NY 2 19

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