Oligomers which inhibit expression of collagen genes
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United States of America Patent
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Jul 14, 1998
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Feb 18, 1997
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Sep 15, 1995
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Abstract
Oligomers which inhibit expression of a collagen gene are described. It is believed that each oligomer, when introduced into a cell, forms a transcription-inhibiting complex composed of the oligomer and the collagen-gene promoter region. The oligomer, preferably a phosphorothioate deoxyoligonucleotide, preferably binds in the antiparallel orientation to the polypurine strand of a polypurine-polypyrimidine region of the promoter region of a mammalian .alpha.1 (I) collagen gene.
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