Biflavanoids and derivatives thereof as antiviral agents

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United States of America Patent

PATENT NO 5773462
SERIAL NO

08668284

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Abstract

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Substantially purified antiviral biflavanoids robustaflavone, hinokiflavone, amentoflavone, agathisflavone, volkensiflavone, morelloflavone, rhusflavanone, succedaneaflavanone, GB-1a, and GB-2a are provided. Antiviral biflavanoid derivatives and salt forms thereof, e.g., robustaflavone tetrasulfate potassium salt, and methods for preparing the same are also disclosed. Pharmaceutical compositions which include the antiviral biflavanoids, derivatives or salts thereof are also provided. Also disclosed is an improved method for obtaining substantially pure robustaflavone from plant material. The biflavanoid compounds, derivatives or salts thereof of the invention may be used in a method for treating and/or preventing viral infections caused by viral agents such as influenza, e.g., influenza A and B; hepatitis, e.g., hepatitis B; human immunodeficiency virus, e.g., HIV-1; Herpes viruses (HSV-1 and HSV-2); Varicella Zoster virus (VZV); and measles.

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Patent Owner(s)

Patent OwnerAddress
ADVANCED LIFE SCIENCES INC12305 SOUTH NEW AVENUE LEMONT IL 60439

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Flavin, Michael T Darien, IL 32 230
Lin, Yuh-Meei Naperville, IL 8 22
Schure, Ralph Darien, IL 4 14
Zembower, David E Oak Park, IL 24 202
Zhao, Gen-Xian Woodridge, IL 2 5

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