Method of preparing a synergistic immunological adjuvant formulation
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Jun 30, 1998
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Jul 21, 1995
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Sep 27, 1993
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Abstract
The improved method uses N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) or N-acetylglucosaminyl-N-acetyl-muramyl-L-alanyl-D-isoglutamine (GMDP) in low dose ranges in a combination with zinc-L-proline complex and with immunostimulating lipid in doses which synergistically potentiate the effect of each single component whereby the zinc-L-proline complex contains an excess of L-proline or 5-oxo-L-proline which serves as a solubiliser and dispersing agent for the lipid component.
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