Non invasive identification of intestinal ischemia from measurement of basic electrical rhythm of intestinal smooth muscle electrical activity using a magnetometer

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United States of America Patent

PATENT NO 5771894
SERIAL NO

08847838

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Abstract

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Intestinal ischemia is diagnosed non-invasively by scanning the abdomen externally with a SQUID magnetometer which measures the magnetic field produced by smooth muscle electrical activity. These measurements are processed to determine the basic electrical rhythm (BER) frequency at various locations along the intestine. A nominal value for the BER frequency is established at each location, and if the measured value falls below the associated nominal value by more than a predetermined margin, ischemia at that location is indicated. Ischemia is further indicated by an interval of arrhythmia in which the BER frequency increases to a range of about 24-180 cpm or at least about twice the nominal value. The BER frequency values are presented on a graphic display which provides an indication of the nominal value at an affected location from the gradient of the measured values at adjacent normal locations. Also, a gradual reduction in the local BER frequency at a particular location is an indication of progressive ischemia, while an absence of BER activity in a section of intestine indicates necrosis.

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Patent Owner(s)

Patent OwnerAddress
VANDERBILT UNIVERSITYNASHVILLE TN 37212

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bradshaw, Leonard A Nashville, TN 1 28
Golzarian, Javad Stoneybrook, NY 1 28
Richards, William O Nashville, TN 1 28
Staton, Daniel J Nashville, TN 1 28
Wikswo, Jr John P Brentwood, TN 9 249

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