Synthesis of taxol, taxol analogs and their intermediates with variable A-ring side chain structures and compositions thereof
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
-
Jun 23, 1998
Issued Date -
N/A
app pub date -
Dec 15, 1994
filing date -
Feb 5, 1993
priority date (Note) -
In Force
status (Latency Note)
Importance
Abstract
An efficient protocol for the synthesis of taxol, taxol analogs and their intermediates is described. The process incudes the attachment of the taxol A-ring side chain to baccatin III and for the synthesis of taxol and taxol analogs with variable A-ring side chain structures. A rapid and highly efficient esterification of O-protected isoserine and 3-phenylisoserine acids having N-benzyoloxycarbonyl groups to the C-13 hydroxyl of 7-O-protected baccatin III is followed by a deprotection-acylation sequence to make taxol, celphalomanninne and various analogs, including photoaffinity labeling candidates.
First Claim
Family
International Classification(s)
Cited Art Landscape
Patent Citation Ranking
Recipient Email Address
Recipient Email Address
Comment
Recipient Email Address
Add to Portfolio(s)
To add this patent to one, or more, of your portfolios, simply click the add button.
This Patent is in these Portfolios:
Add to additional portfolios:
Last Refreshed On:
Changes done successfully