Gas filled liposomes and stabilized gas bubbles and their use as ultrasonic contrast agents
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United States of America Patent
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Jun 23, 1998
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Feb 22, 1994
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Dec 22, 1989
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Abstract
Contrast agents for ultrasonic imaging comprising gas filled liposomes prepared using vacuum drying gas instillation methods, and gas filled liposomes substantially devoid of liquid in the interior thereof, are described. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in ultrasonic imaging applications are also disclosed. Also described are diagnostic kits for ultrasonic imaging which include the subject contrast agents.
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