recombinant poxviruses with foreign DNA in essential regions
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United States of America Patent
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Jun 16, 1998
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N/A
app pub date -
Mar 14, 1996
filing date -
Apr 29, 1994
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Abstract
Defective poxviruses that lack a function imparted by an essential region of its parental poxvirus are provided for protein production and vaccination. A DNA polynucleotide encoding a protein is inserted into the defective poxvirus and placed under transcriptional control of a promoter. The defective poxvirus is viable when the lost function of the essential region is complemented by a host cell, transgenic animal or helper virus.
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