Kit containing d-arabinitol dehydrogenase and NAD+ for determining d-arabinitol
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United States of America Patent
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Jun 16, 1998
Issued Date -
N/A
app pub date -
Jun 7, 1995
filing date -
Jul 12, 1991
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Expired
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Abstract
A D-arabinitol dehydrogenase enzyme is prepared that is capable of catalyzing the oxidation of D-arabinitol and substantially incapable of catalyzing the oxidation of D-mannitol and is substantially free of other enzymes capable of oxidizing D-mannitol. The enzyme is preferably obtained from Candida tropicalis ATCC 750 or Candida shehatae. The enzyme may also be obtained by recombinant DNA technology. Monoclonal antibodies are produced against the enzyme and can be used to identify the enzyme. The enzyme is used for detecting the presence of Candida in a host such as detecting Candida infection in a patient by determining the presence of D-arabinitol in a sample. The oxidation of D-arabinitol by nicotinamide adenine dinucleotide (NAD.sup.+) is catalyzed by the enzyme and the amount of NADH produced in a given time is determined. Also prepared is a composition containing the enzyme and NAD.sup.+ and a kit containing a packaged combination of the enzyme and NAD.sup.+.
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