Inhibitors of cell-medicated disorders
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United States of America Patent
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Jun 9, 1998
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N/A
app pub date -
Feb 14, 1994
filing date -
Feb 14, 1994
priority date (Note) -
Expired
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Abstract
The present invention provides a method for blocking a cellular proton pump that comprises contacting a cell with a cellular proton pump-blocking effective quantity of In-EDTA or Tl-EDTA. The present invention also provides a method of treating or preventing cell-mediated disorders in a vertebrate animal by administering In-EDTA or Tl-EDTA to the vertebrate animal, as well as a method for stopping the cellular proton pump-blocking effect of Group IIIa metals such as Ga, In, and Tl, through use of suitable chelating agents. Suitable compositions for use in the aforementioned methods are provided as well.
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