Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method
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United States of America Patent
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Jun 2, 1998
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app pub date -
Dec 17, 1996
filing date -
Dec 17, 1996
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Abstract
Novel compounds are provided which are inhibitors of MTP and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases, and have the structure ##STR1## including pharmaceutically acceptable salts thereof or prodrug esters thereof, wherein q is 0, 1 or 2; R.sup.x is H, alkyl, aryl or halogen; A is (1) a bond; (2) --O--; or (3) ##STR2## B is: ##STR3## and wherein L.sup.2, L.sup.1, R.sup.1, R.sup.2, R.sup.3, R.sup.3', R.sup.3a, R.sup.3b, R.sup.4, R.sup.4', R.sup.5, X, ##STR4## are as defined herein.
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