Production of human serum alubumin A
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United States of America Patent
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Jun 2, 1998
Grant Date -
N/A
app pub date -
Oct 5, 1989
filing date -
Oct 26, 1988
priority date (Note) -
Expired
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Abstract
A process for the production of human serum albumin A (HSA) characterized by culturing host cells transformed with the plasmids containing a leader DNA sequence and a cDNA coding for mature HSA to produce and secrete mature HSA, and recovering the mature HSA. As the leader HSA sequence, a cDNA coding for the prepro sequence of HSA, a synthetic DNA coding for the prepro sequence of HSA, by the codons frequently used in a selected host, a DNA coding for a chimeric leader peptide, a DNA coding for MF.alpha.1 prepro sequence, or a DNA coding for PH05 signal peptide, is used.
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