Lyophilized pharmaceutical preparations capable of providing aqueous drug composition having property of reversible thermosetting gelation
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United States of America Patent
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May 26, 1998
Grant Date -
N/A
app pub date -
Apr 14, 1997
filing date -
Oct 13, 1994
priority date (Note) -
Expired
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Abstract
Herein disclosed is a lyophilized pharmaceutical preparation obtained by lyophilizing an aqueous composition having property of reversible thermosetting gelation and comprising an effective amount of a drug, 0.2 to 2.1 (W/V)% of methylcellulose (the content of methoxyl group is within the range of 26 to 33%), 1.2 to 2.3 (w/v)% of citric acid and 0.5 to 13 (W/V)% of polyethylene glycol. The lyophilized pharmaceutical preparation makes it possible to stably store drugs unstable to water till they are put into practical use and, upon therapeutic use, an aqueous composition having property of reversible thermosetting gelation which can undergo gelation when locally applied can easily and immediately be reconstituted from the preparation by addition of a proper amount of a solvent for reconstitution.
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