Inhibition of cell proliferation using antisense oligonucleotides
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United States of America Patent
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May 26, 1998
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app pub date -
Jan 26, 1994
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Jan 14, 1992
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Abstract
The present invention provides a method of inhibiting restenosis of a blood vessel in a mammal after mechanical treatment of the vessel to reduce a stenosis. The method includes contacting proliferating smooth muscle cells in the vessel with an antisense oligonucleotide directed against a cellular division cycle gene product. This gene product can be one of the following: c-myc, PCNA, and cyclin B.sub.1. The antisense oligonucleotide is used in an amount effective to inhibit translation of the cellular division cycle gene product in the cell.
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