Agents for inhibiting the production of IL-1.beta. and the release of TNF.alpha.
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United States of America Patent
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May 19, 1998
Grant Date -
N/A
app pub date -
Dec 22, 1995
filing date -
Dec 26, 1994
priority date (Note) -
Expired
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Abstract
The pharmaceutical use of 1-cinnamoyl-2-pyrrolidinone derivatives having the activities to inhibit the production of IL-1.beta. and the release of TNF.alpha.. Those derivatives are useful in the treatment or prophylaxis of the diseases such as chronic rheumatism and sepsis.
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