Cationic lipid acid salt of 3beta?N- (N', N'-dimethylaminoethane) -carbamoyl!cholestrol and halogenated solvent-free preliposomal lyophilate thereof
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United States of America Patent
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May 19, 1998
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N/A
app pub date -
Jun 7, 1995
filing date -
Jun 7, 1995
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Abstract
This invention discloses a novel cationic lipid acid salt of 3.beta.?N-(N',N'-dimethylaminoethane)-carbamoyl!cholesterol. This invention further discloses a transmembrane compatible body suitable for transfection of animals and animal cells with nucleotides such as DNA, RNA, and synthetic nucleotides. Such transmembrane compatible bodies arise from hydratable non-liposomal halogenated solvent-free lyophilate comprising 3.beta.?N-(N',N'-dimethylaminoethane)-carbamoyl!cholesterol and DOPE. This invention yet further discloses a halogenated solvent-free aqueous solution, suitable for lyophilization into a preliposomal powder, wherein the solution comprises 3.beta.?N-(N',N'-dimethylaminoethane)-carbamoyl!cholesterol wherein substantially all 3.beta.?N-(N',N'-dimethylaminoethane)-carbamoyl!cholesterol is dissolved.
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