Methods of detecting nucleic acids with nucleotide probes containing 4'-substituted nucleotides and kits therefor
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United States of America Patent
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May 12, 1998
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May 2, 1995
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Dec 9, 1993
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Abstract
This invention relates to use of oligonucleotides having at least one nucleotide that is substituted at the 4'-position of the sugar moiety with a substituent other than hydrogen as nucleotide probes in methods for detecting the presence or amount of a polynucleotide analyte in a sample suspected of containing the polynucleotide analyte. These oligonucleotides can also be packaged in diagnostic assay kits.
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