Linear adhesion inhibitors

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 5747457
SERIAL NO

08329820

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Abstract

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Linear peptides of the formula I X-A-Cys(R.sup.1)-B-Z I, in which A, B, R.sup.1, X and Z are as defined, are highly active inhibitors of the binding of the blood platelet integrin GP IIbIIIa (a.sub.IIb .beta..sub.3) to natural ligands and are suitable, inter alia, for the prophylaxis and for the treatment of circulatory disorders, thrombosis, myocardial infarction, coronary heart disease, arteriosclerosis, atherosclerosis, tumors and osteolytic diseases, and have a supporting effect in wound healing processes.

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Patent Owner(s)

Patent OwnerAddress
MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNGDARMSTADT

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Diefenbach, Beate Darmstadt, DE 13 129
Felding-Habermann, Brunhilde La Jolla, CA 7 75
Jonczyk, Alfred Darmstadt, DE 60 565
Rippmann, Friedrich Heidelberg, DE 6 69

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