Targeted gene expression using preproendothelin-1 promoters
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United States of America Patent
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May 5, 1998
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Feb 28, 1995
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Jun 3, 1994
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Abstract
This invention provides a vector for expression of a nucleic acid cassette in bronchial epithelial and vascular endothelial cells comprising a segment of the 5'-flanking region of the preproendothelin-1 gene, upstream from the transcription start site, the first exon of the preproendothelin-1 gene, and a nucleic acid cassette, wherein the nucleic acid cassette is located within the first exon, in sequential and positional relationship for expression of the nucleic acid cassette.
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