Methods for obtaining production of a gene product in a host cell in vivo or in vitro using a DNA molecule for integration site independent gene expression
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United States of America Patent
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Apr 28, 1998
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Jun 7, 1995
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Aug 7, 1987
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Abstract
Vectors for the integration of a gene into the genetic material of a mammalian host cell such that the gene may be expressed by the host cell comprise a promoter and the gene and include a dominant activator sequence capable of eliciting host cell-type restricted, integration site independent, copy number dependent expression of the gene.
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