Negative contrast agents for magnetic resonance imaging comprising barium sulfate and a clay
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United States of America Patent
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Apr 21, 1998
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N/A
app pub date -
Nov 13, 1995
filing date -
May 20, 1993
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Abstract
A negative contrast agent for MRI is an aqueous suspension having a quantity of barium sulfate between 25 and 30 percent by weight and a quantity of bentonite between 2.5 and 3.5 percent by weight in which a substantial portion of the barium sulfate particles have a mean diameter of at least 10 microns. This negative contrast agent provides dark imaging in a T2 weighted pulse sequence; namely a relative signal intensity (RSI) approaching zero. It also provides a relative signal intensity (RSI) of under 30 percent of that of a reference that approximates tissue in a T1 weighted pulse sequence.
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