Vectors and prokaryotes which autocatalytically delete antibiotic resistance

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United States of America Patent

PATENT NO 5736367
SERIAL NO

08425380

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Abstract

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A vector and a prokaryote transformed therewith which includes nucleic acid sequences which make possible the autocatalytic deletion of nucleotide sequences encoding an antibiotic resistance phenotype. The prokaryote can be a bacterium, and in particular a mycobacterium. Such transformed mycobacteria may be employed in vaccines, thereby eliminating the attendant risk of vaccines including antibiotic resistance markers.

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Patent Owner(s)

Patent OwnerAddress
ALBERT EINSTEIN COLLEGE OF MEDICINE INC1300 MORRIS PARK AVENUE BRONX NY 10461

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hanson, Mark S Columbia, MD 5 69
Hatfull, Graham Pittsburgh, PA 2 11
Haun, Shirley L Gaithersburg, MD 1 11
Jacobs, William R City Island, NY 19 373
Stover, Charles K Mercer Island, WA 19 143

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  • 11 Citation Count
  • C12N Class
  • 56.27 % this patent is cited more than
  • 27 Age
Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges101566725117661601 - 1011 - 2021 - 3031 - 4041 - 5051 - 6061 - 7081 - 90100 +0102030405060708090100110120130140150160170

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