Peptides effective for diagnosis and detection of hepatitis C infection
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United States of America Patent
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Apr 7, 1998
Grant Date -
N/A
app pub date -
Sep 19, 1995
filing date -
Nov 1, 1994
priority date (Note) -
Expired
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Abstract
The present invention relates to novel linear and branched peptides specific for the diagnosis and prevention of hepatitis C virus (HCV) infection. More particularly, the present invention is directed to linear and branched synthetic peptides containing at least one antigenic site which is effective for detecting HCV-associated antibodies in patients using immunoassay techniques. In some cases, these peptides are also library peptides with degenerate amino acid positions. Preferred mixtures for detection of HCV antibodies are provided as well as a novel spliced peptide useful for blocking the non-specific reactivity of certain NS-3 conformational epitopes.
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