Avian herpesvirus-based live recombinant avian vaccine, in particular against Gumboro disease
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United States of America Patent
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Mar 31, 1998
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Jan 5, 1995
filing date -
Dec 30, 1994
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Abstract
The present invention relates to vaccines for avian use which are based on live recombinant avian herpesviruses, in particular the Marek's disease viruses including HVT virus (herpesvirus of turkey), in which has been inserted, by genetic recombination, at least one nucleotide sequence which encodes and expresses an antigenic polypeptide of an avian pathogen under conditions which ensure immunization leading to efficient protection of the vaccinated animal against the pathogen. In one embodiment, the antigenic polypeptide is inserted in the UL43 gene under the control of the CMV immediate early promoter. The vaccines of the present invention are advantageous over previously used vaccines in that they can be used to ensure total protection of animals against Gumboro disease and to immunize chicks as young as one-day old without secondary effects, and only require low doses.
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