C.sup.ac -methylphosphonamidites and methods for preparing methylphosphonates

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United States of America Patent

PATENT NO 5731429
SERIAL NO

08544683

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Abstract

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A compound of general formula ##STR1## wherein R is methyl R' is selected from the group consisting of trityl and pixyl, and R' is H or OMe. These compounds may advantageously be employed in the synthesis of oligonucleotides by conventional methods, such as automated solid phase synthesis. Use of ethylene diamine in the cleavage and deprotection procedure substantially eliminates the formation of undesirable side products.

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BECKMAN INSTRUMENTS INCCALIFORNIA USA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Farooqui, Firdous Brea, CA 22 493
Hanna, Naeem B Fullerton, CA 9 161
Reddy, Meda Parameswara Brea, CA 4 26

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  • 5 Citation Count
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  • 7.50 % this patent is cited more than
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Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges9632962111122301 - 1011 - 2021 - 3031 - 4041 - 5051 - 6061 - 7071 - 8081 - 9091 - 100100 +0510152025303540455055606570

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