Peptide derivatives
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United States of America Patent
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Mar 3, 1998
Grant Date -
N/A
app pub date -
Apr 7, 1993
filing date -
May 8, 1989
priority date (Note) -
Expired
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Abstract
The present invention relates to certain peptide derivatives, as described herein, which are human leukocyte elastase (HLE) inhibitors making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated, including treatment of tissue degenerative diseases such as pulmonary emphysema. The invention also includes intermediates useful in the synthesis of these peptide derivatives, processes for preparing them, pharmaceutical compositions containing such peptide derivatives and methods for their use.
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