9-oxo-1-azabicyclo?5.2.0!non-2,4-diene-2-carboxylic acid compounds as antibiotics

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United States of America Patent

PATENT NO 5719139
SERIAL NO

08587903

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention provides a compound of the formula (I): ##STR1## wherein R.sup.1 is hydrogen, optionally substituted; acylamino, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.1-6 alkoxy, C.sub.1-6 alkanoyloxy, C.sub.1-6 alkylamino, di-(C.sub.1-6 alkyl)amino, C.sub.1-6 alkoxycarbonyl, aminocarbonyl, C.sub.1-6 alkylaminocarbonyl or di-(C.sub.1-6 alkyl)aminocarbonyl; R.sup.2 is hydrogen or C.sub.1-6 alkoxy; or R.sup.1 and R.sup.2 together form optionally substituted C.sub.1-6 alkylene; R.sup.3 and R.sup.5 are independently hydrogen or C.sub.1-6 alkyl; and one of R.sup.4 and R.sup.6 is hydrogen or C.sub.1-4 alkyl and the other is selected from a number of groups or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof. Processes of their preparation, intermediates in their preparation, their use as therapeutic agents and pharmaceutical compositions containing them.

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Patent Owner(s)

Patent OwnerAddress
ZENECA LIMITED9 MILLBANK IMPERIAL CHEMIC HOUSE LONDON SW1P
ZENECA-PHARMA SA1 RUE DES CAHUFFOURS BOITE POSTALE 127 F-95022 CERGY CEDEX

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Koza, Patrice Jacky Daniel Sillery, FR 1 1
Lohmann, Jean-Jacques Marcel Merfy, FR 15 482

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