Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
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United States of America Patent
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Feb 3, 1998
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app pub date -
Jan 13, 1995
filing date -
Mar 9, 1992
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Abstract
The present invention provides methods for producing mutationally-altered immunoglobulins and compositions containing such mutationally-altered immunoglobulins, wherein the mutationally-altered immunoglobulins have at least one mutation that alters the pattern of glycosylation in a variable region and thereby modifies the affinity of the immunoglobulin for a preselected antigen. The methods and compositions of the invention provide immunoglobulins that possess increased affinity for antigen. Such glycosylation-altered immunoglobulins are suitable for diagnostic and therapeutic applications.
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