Interferon polymer conjugates
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United States of America Patent
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Jan 27, 1998
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N/A
app pub date -
Nov 10, 1994
filing date -
Nov 10, 1993
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Abstract
A process is disclosed for preparing long-acting alpha interferon-containing compositions. Alpha interferon is contacted with a relatively small molar excess of a substantially non-antigenic polymer in the presence of a surfactant to preserve bioactivity. Isolation of the desired conjugate species having optimal activity is also disclosed.
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