Preparation of substituted thiazoles
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United States of America Patent
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Jan 6, 1998
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N/A
app pub date -
Sep 9, 1996
filing date -
Sep 14, 1995
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Abstract
A process for the preparation of a substituted thiazole comprises reacting an isothiocyanate compound of the general formula Hal.CH(R.sub.1). CH.dbd.C(R.sub.2).NCS in which Hal is a chlorine or bromine atom and R.sub.1 and R.sub.2 is each a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms, in solution with a chlorinating or brominating agent. The compound 2-chloro-5-(chloromethyl) thiazole, which is an important intermediate in the manufacture of agrochemical and pharmaceutical products, may very advantageously be prepared by this method.
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