Oligonucleotides that inhibit production of .alpha.-tumor necrosis factor
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United States of America Patent
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Jan 6, 1998
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N/A
app pub date -
Nov 18, 1994
filing date -
Aug 23, 1989
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Abstract
A sequence of anti-direction, anti-messenger RNA oligonucleotides of .alpha.-TNF characterized in that it possesses the structure of the formula ##STR1## wherein X is hydrogen, or a sequence of 1 to 17 oligonucleotides in free form, in alkylated form, in sulfurated form or in the form of a poly L-lysine derivative useful for stopping the production of .alpha.-TNF.
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