High-throughput screening assay for inhibitors of nucleic acid helicases
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United States of America Patent
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Jan 6, 1998
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N/A
app pub date -
Mar 14, 1996
filing date -
Mar 14, 1996
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Abstract
The invention provides screening assays for identifying an inhibitor of a pathogenic helicase activity, e.g. a helicase derived from a pathogenic infectious organism such as a bacterium, protozoan or fungus. Helicase activity is detected by the solid-phase, preferential capture of retained (non-liberated) single-stranded nucleic acid comprising a detectable label.
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